Read Yvette Wong's Publications 

~ Research from Yvette Wong's Lab ~ 

~ Inter-Organelle Contact Sites: Function and Misregulation in Neurodegenerative Disease ~

1. TDP-43 oxidation and PP1 crosstalk at RNA granule-mitochondria contact sites.

Nature Communications. 2026. *In Press.
Ball HE, Woods AC, Wong YC.

https://pubmed.ncbi.nlm.nih.gov/42248860/

2. Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.
   Proc Natl Acad Sci U S A. 2023 Oct 31;120(44):e2313010120. PMID: 37878717
   Wong YC*^, Jayaraj ND*, Belton TB, Shum GC, Ball HE, Ren D, Tadenev ALD, Krainc D, Burgess RW, Menichella DM^. *Co-First Author, ^Co-Corresponding Author.
   https://pubmed.ncbi.nlm.nih.gov/37878717/

3. Super-resolution microscopy: Insights into mitochondria-lysosome crosstalk in health and disease.
   Journal of Cell Biology. 2023 Dec 4;222(12):e202305032. PMID: 37917024. REVIEW.
   Leisten ED, Woods AC, Wong YC.
   https://pubmed.ncbi.nlm.nih.gov/37917024/

4. Live cell microscopy of mitochondria-lysosome contact site formation and tethering dynamics.
   STAR Protocols. 2022 Mar 18;3(2):101262. PMID: 35330964
   Belton TB, Leisten ED, Cisneros J, Wong YC.
   https://pubmed.ncbi.nlm.nih.gov/35330964/

5. Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases.
   Trends in Neurosciences. 2022 Apr;45(4):312-322. PMID: 35249745. REVIEW.
   Cisneros J, Belton TB, Shum GC, Molakal CG, Wong YC.
   https://pubmed.ncbi.nlm.nih.gov/35249745/

~ Molecular Pathways in Neurological Diseases ~

6. Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer's Disease Pathologies in Neurons.

bioRxiv. 2025 Dec 14:2025.12.14.694212. doi: 10.64898/2025.12.14.694212.

Linden AK, Affaneh A, Aylward A, Wong YC, Kessler JA, Peng CY. 

https://pubmed.ncbi.nlm.nih.gov/41415446/

7. Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
   Glia. 2023 Sep;71(9):2180-2195. PMID: 37203250
   Chen Y, Quan S, Patil V, Kunjamma RB, Tokars HM, Leisten ED, Joy G, Wills S, Chan JR, Wong YC, Popko B.
   https://pubmed.ncbi.nlm.nih.gov/37203250/

8. Neurons undergo pathogenic metabolic reprogramming in models of familial ALS.
   Molecular Metabolism. 2022 Mar 3;60:101468. PMID: 35248787
   Riechers SP, Mojsilovic-Petrovic J, Belton TB, Chakrabarty RP, Garjani M, Medvedeva V, Dalton C, Wong YC, Chandel NS, Dienel G, Kalb RG.
   https://pubmed.ncbi.nlm.nih.gov/35248787/

~ Yvette Wong's Postdoctoral Research ~ 

~ Mitochondria-Lysosome Contact Sites: Roles and Regulation ~

9. Mitochondria-lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis.
   Nature. 2018 Feb 15;554(7692):382-386. PMID: 29364868
   Wong YC, Ysselstein D, Krainc D.
   https://pubmed.ncbi.nlm.nih.gov/29364868

10. Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2.
    Developmental Cell. 2019 Aug 5;50(3):339-354.e4. PMID: 31231042
    Wong YC*, Peng W*, Krainc D. *Co-First Author.
    https://pubmed.ncbi.nlm.nih.gov/31231042

11. Regulation and Function of Mitochondria-Lysosome Membrane Contact Sites in Cellular Homeostasis.
    Trends in Cell Biology. 2019 Jun;29(6):500-513. PMID: 3089842. REVIEW.
    Wong YC, Kim S, Peng W, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/30898429

12. Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via lysosomal TRPML1.
    Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19266-19275. PMID: 32703809
    Peng W, Wong YC, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/32703809/

13. Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease.
    Nature Communications. 2021 Mar 22;12(1):1807. PMID: 33753743
    Kim S, Wong YC, Gao F, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/33753743/

14. Mid51/Fis1 mitochondrial oligomerization complex drives lysosomal untethering and network dynamics.
    Journal of Cell Biology. 2022 Oct 3;221(10):e202206140. PMID: 36044022
    Wong YC*^, Kim S*, Cisneros J, Molakal CG, Song P, Lubbe SJ, Krainc D^. *Co-First Author, ^Co-Corresponding Author.
    https://pubmed.ncbi.nlm.nih.gov/36044022/

15. Parkin regulates amino acid homeostasis at mitochondria-lysosome (M/L) contact sites in Parkinson’s disease.
    Science Advances. 2023 Jul 21;9(29):eadh3347. PMID: 37467322
    Peng W, Schröder LF, Song P, Wong YC, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/37467322/

~ Parkinson’s Disease: Cellular Mechanisms/Biomarkers & Reviews ~

16. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease.

Science. 2017 Sep 22;357(6357):1255-1261. PMID: 28882997

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/28882997

17. The Parkinson’s disease-linked protein TMEM230 is required for Rab8a-mediated secretory vesicle trafficking and retromer trafficking.

Human Molecular Genetics. 2017 Feb 15;26(4):729-741. PMID: 28115417

Kim MJ, Deng HX, Wong YC, Siddique T, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/28115417

18. Analysis of blood-based gene expression in idiopathic Parkinson disease.

Neurology. 2017 Oct 17;89(16):1676-1683. PMID: 28916538

Shamir R, Klein C, Amar D, Vollstedt EJ, Bonin M, Usenovic M, Wong YC, Maver A, Poths S, Safer H, Corvol JC, Lesage S, Lavi O, Deuschl G, Kuhlenbaeumer G, Pawlack H, Ulitsky I, Kasten M, Riess O, Brice A, Peterlin B, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/28916538

19. Increased Lysosomal Exocytosis Induced by Lysosomal Ca2+ Channel Agonists Protects Human Dopaminergic Neurons from α-Synuclein Toxicity.

Journal of Neuroscience. 2019 Jul 17;39(29):5760-5772. PMID: 31097622

Tsunemi T, Perez-Rosello T, Ishiguro Y, Yoroisaka A, Jeon S, Hamada K, Rammonhan M, Wong YC, Xie Z, Akamatsu W, Mazzulli JR, Surmeier DJ, Hattori N, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/31097622

20. Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. 

Neuron. 2023 Sep 13:S0896-6273(23)00629-3. PMID: 37716354 

Song P, Peng W, Sauve V, Fakih R, Xie Z, Ysselstein D, Krainc T, Wong YC, Mencacci NE, Savas JN, Surmeier DJ, Gehring K, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/37716354/

21. VPS13C regulates phospho-Rab10-mediated lysosomal function in human dopaminergic neurons.

Journal of Cell Biology. 2024 May 6;223(5):e202304042. PMID: 38358348

Schrӧder LF, Peng W, Gao G, Wong YC, Schwake M, Krainc D.

https://pubmed.ncbi.nlm.nih.gov/38358348/

22. Lysosomal trafficking defects link Parkinson’s disease with Gaucher’s disease.
    Movement Disorders. 2016 Nov;31(11):1610-1618. PMID: 27619775. REVIEW.
    Wong YC, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/27619775

23. α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies.
    Nature Medicine. 2017 Feb 7;23(2):1-13. PMID: 28170377. REVIEW.
    Wong YC, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/28170377

24. Neuronal vulnerability in Parkinson disease: Should the focus be on axons and synaptic terminals?
    Movement Disorders. 2019 Oct;34(10):1406-1422. PMID: 31483900. REVIEW.
    Wong YC, Luk K, Purtell K, Burke Nanni S, Stoessl AJ, Trudeau LE, Yue Z, Krainc D, Oertel W, Obeso JA, Volpicelli-Daley LA.
    https://pubmed.ncbi.nlm.nih.gov/31483900

25. Synaptic, Mitochondrial, and Lysosomal Dysfunction in Parkinson’s Disease.
    Trends in Neurosciences. 2019 Feb;42(2):140-149. PMID: 30509690. REVIEW.
    Nguyen M, Wong YC, Ysselstein D, Severino A, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/30509690

~ Cellular mechanisms in Frontotemporal Dementia & Optic Neuropathy ~

26. Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.
    Human Molecular Genetics. 2017 Dec 15;26(24):4861-4872. PMID: 29036611
    Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D.
    https://pubmed.ncbi.nlm.nih.gov/29036611

27. Dominant mutations in MIEF1 affect mitochondrial dynamics and cause a singular late onset optic neuropathy.
    Molecular Neurodegeneration. 2021 Feb 25;16(1):12. PMID: 33632269
    Charif M*, Wong YC*, Kim S, Guichet A, Vignal C, Zanlonghi X, Bensaid P, Procaccio V, Bonneau D, Amati-Bonneau P, Reynier P, Krainc D, Lenaers G. *Co-First Author.
    https://pubmed.ncbi.nlm.nih.gov/33632269

~ Yvette Wong's PhD Research ~ 

~ Actin Regulation of Mitochondrial Dynamics ~

28. Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission-fusion balance within mitochondrial networks.
    Nature Communications. 2016 Sep 30;7:12886. PMID: 27686185
    Moore AS*, Wong YC*, Simpson CL, Holzbaur EL. *Co-First Author.
    https://pubmed.ncbi.nlm.nih.gov/27686185

29. Mitochondrially-associated actin waves maintain organelle homeostasis and equitable inheritance.
    Current Opinion in Cell Biology. 2024 Apr 30;88:102364. PMID: 38692079. REVIEW.
    Coscia SM, Moore AS, Wong YC, Holzbaur ELF.
    https://pubmed.ncbi.nlm.nih.gov/38692079/

~ ALS-associated Optineurin is an Autophagy Receptor for Mitochondria ~

30. Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation.
    Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4439-48. PMID: 25294927
    Wong YC, Holzbaur EL.
    https://pubmed.ncbi.nlm.nih.gov/25294927

31. Temporal dynamics of PARK2/parkin and OPTN/optineurin recruitment during the mitophagy of damaged mitochondria.
    Autophagy. 2015;11(2):422-4. PMID: 25801386. REVIEW.
    Wong YC, Holzbaur EL.
    https://pubmed.ncbi.nlm.nih.gov/25801386

~ Huntingtin Regulates Autophagosome Axonal Transport ~

32. The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
    Journal of Neuroscience. 2014 Jan 22;34(4):1293-305. PMID: 24453320
    Wong YC, Holzbaur EL.
    https://pubmed.ncbi.nlm.nih.gov/24453320

33. Autophagosome dynamics in neurodegeneration at a glance.
    Journal of Cell Science. 2015 Apr 1;128(7):1259-67. PMID: 25829512. REVIEW.
    Wong YC, Holzbaur EL.
    https://pubmed.ncbi.nlm.nih.gov/25829512

~ Identifying Parkinson's Disease Biomarkers ~

34. Plasma apolipoprotein A1 as a biomarker for Parkinson disease.

Annals of Neurology. 2013 Jul;74(1):119-27. PMID: 23447138

Qiang JK*, Wong YC*, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, B Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, Chen-Plotkin AS. *Co-First Author.

https://pubmed.ncbi.nlm.nih.gov/23447138

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